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A Polystyrene‐Supported, Highly Recyclable Squaramide Organocatalyst for the Enantioselective Michael Addition of 1,3‐Dicarbonyl Compounds to β‐Nitrostyrenes
Author(s) -
Kasaplar Pinar,
Riente Paola,
Hartmann Caroline,
Pericàs Miquel A.
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200526
Subject(s) - squaramide , chemistry , enantioselective synthesis , michael reaction , organocatalysis , cycloaddition , polystyrene , organic chemistry , catalysis , combinatorial chemistry , polymer
A chiral squaramide has been supported onto a polystyrene (PS) resin through a copper‐catalyzed azide–alkyne cycloaddition (CuAAC) reaction and used as a very active, easily recoverable and highly reusable organocatalyst for the asymmetric Michael addition of 1,3‐dicarbonyl compounds to β‐nitrostyrenes. The PS‐supported squaramide could be recycled up to 10 times.