Water‐Soluble Chiral Ruthenium(II) Phenyloxazoline Complex: Reusable and Highly Enantioselective Catalyst for Intramolecular Cyclopropanation Reactions | Zendy

AbuElfotoh AbdelMoneim | Zendy; Nguyen Diem Phuong Thi | Zendy; Chanthamath Soda | Zendy; Phomkeona Kesiny | Zendy; Shibatomi Kazutaka | Zendy; Iwasa Seiji | Zendy

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Water‐Soluble Chiral Ruthenium(II) Phenyloxazoline Complex: Reusable and Highly Enantioselective Catalyst for Intramolecular Cyclopropanation Reactions

Author(s) -

AbuElfotoh AbdelMoneim,

Nguyen Diem Phuong Thi,

Chanthamath Soda,

Phomkeona Kesiny,

Shibatomi Kazutaka,

Iwasa Seiji

Publication year - 2012

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201200508

Subject(s) - cyclopropanation , chemistry , ruthenium , intramolecular force , enantioselective synthesis , oxazoline , catalysis , allylic rearrangement , hydroxymethyl , ether , organic chemistry , medicinal chemistry

The intramolecular cyclopropanation of various trans ‐allylic diazoacetates and alkenyl diazoketones has been achieved with excellent enantioselectivities of up to 98% ee and in quantitative yields by using a water‐soluble ruthenium(II)/hydroxymethyl(phenyl)oxazoline catalyst in a water/ether biphasic medium. The catalyst could be reused at least five times.

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