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Salt‐Controlled Selectivity in “on Water” and “in Water” Passerini‐Type Multicomponent Reactions
Author(s) -
Sela Tal,
Vigalok Arkadi
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200448
Subject(s) - chemistry , nucleophile , salt (chemistry) , salting out , aqueous solution , selectivity , sodium , sodium salt , aqueous medium , organic chemistry , inorganic chemistry , combinatorial chemistry , catalysis
We have demonstrated that simple sodium salts can completely reverse the product ratios of the Passerini reaction in aqueous media. Furthermore, the use of the “salting‐in” salt and a small excess of the nucleophile gives significantly higher yields than the use of the saturated solution of the nucleophile alone.