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Palladium(II)‐Catalyzed Hydration of Alkynylphosphonates to β‐Ketophosphonates
Author(s) -
Li Xiubin,
Hu Gaobo,
Luo Ping,
Tang Guo,
Gao Yuxing,
Xu Pengxiang,
Zhao Yufen
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200420
Subject(s) - chemistry , palladium , catalysis , mercury (programming language) , combinatorial chemistry , organic chemistry , computer science , programming language
A highly efficient palladium(II)‐catalyzed hydration of a wide range of alkynylphosphonates to the corresponding β‐ketophosphonates has been developed to give high yields at 80 °C in 1, 4‐dioxane, with no acidic or alkaline cocatalysts required. The described catalytic system should provide an efficient alternative to highly toxic mercury‐catalyzed methodologies and be useful in synthetic programs.