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The Copper‐Catalyzed C‐3‐Formylation of Indole CH Bonds using Tertiary Amines and Molecular Oxygen
Author(s) -
Chen Jianbin,
Liu Bin,
Liu Dongfang,
Liu Shan,
Cheng Jiang
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200345
Subject(s) - chemistry , tetramethylethylenediamine , formylation , catalysis , indole test , copper , oxygen , molecular oxygen , functional group , hydrogen bond , polymer chemistry , medicinal chemistry , organic chemistry , molecule , polymer
A copper‐catalyzed formylation reaction has been developed by employing oxygen (O 2 ) as the clean oxidant. The CH bonds of indoles were C‐3‐formylated by tetramethylethylenediamine (TMEDA) and water (H 2 O; in situ formed and external added water) as the carbonyl source in moderate to good yields with good functional group tolerance. Thus, it represents a facile procedure leading to 3‐formylindoles.