The Copper‐Catalyzed C‐3‐Formylation of Indole CH Bonds using Tertiary Amines and Molecular Oxygen | Zendy

Chen Jianbin | Zendy; Liu Bin | Zendy; Liu Dongfang | Zendy; Liu Shan | Zendy; Cheng Jiang | Zendy

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The Copper‐Catalyzed C‐3‐Formylation of Indole CH Bonds using Tertiary Amines and Molecular Oxygen

Author(s) -

Chen Jianbin,

Liu Bin,

Liu Dongfang,

Liu Shan,

Cheng Jiang

Publication year - 2012

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201200345

Subject(s) - chemistry , tetramethylethylenediamine , formylation , catalysis , indole test , copper , oxygen , molecular oxygen , functional group , hydrogen bond , polymer chemistry , medicinal chemistry , organic chemistry , molecule , polymer

A copper‐catalyzed formylation reaction has been developed by employing oxygen (O 2 ) as the clean oxidant. The CH bonds of indoles were C‐3‐formylated by tetramethylethylenediamine (TMEDA) and water (H 2 O; in situ formed and external added water) as the carbonyl source in moderate to good yields with good functional group tolerance. Thus, it represents a facile procedure leading to 3‐formylindoles.

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