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Iron‐Catalyzed CC Bond Cleavage and CN Bond Formation
Author(s) -
Li Wenjuan,
Zheng Xiaojian,
Li Zhiping
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200324
Subject(s) - chemistry , catalysis , bond cleavage , cleavage (geology) , alkylation , medicinal chemistry , stereochemistry , polymer chemistry , organic chemistry , geotechnical engineering , fracture (geology) , engineering
A novel approach for CN bond formation was developed by iron‐catalyzed CC bond cleavage. Anilines and sulfonamides reacted smoothly with 2‐substituted 1,3‐diphenylpropane‐1,3‐diones to afford N ‐alkylation products, in which the 1,3‐dicarbonyl group acts as a leaving group in the presence of an iron catalyst. The reversible CC bond cleavage plays a driving force to give the thermodynamically stable products. The method is complementary to the previous methods for CN bond formation.