Palladium‐Catalyzed, Chelation‐Assisted Stereo‐ and Regioselective Synthesis of Tetrasubstituted Olefins by Oxidative Heck Arylation | Zendy

Lee Hyun Seung | Zendy; Kim Ko Hoon | Zendy; Kim Sung Hwan | Zendy; Kim Jae Nyoung | Zendy

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Palladium‐Catalyzed, Chelation‐Assisted Stereo‐ and Regioselective Synthesis of Tetrasubstituted Olefins by Oxidative Heck Arylation

Author(s) -

Lee Hyun Seung,

Kim Ko Hoon,

Kim Sung Hwan,

Kim Jae Nyoung

Publication year - 2012

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201200306

Subject(s) - regioselectivity , palladium , chemistry , chelation , catalysis , heck reaction , oxidative addition , combinatorial chemistry , organic chemistry , functional group , polymer

An efficient synthesis of tetrasubstituted olefins was achieved via a palladium‐catalyzed, chelation‐assisted oxidative Heck arylation protocol from trisubstituted olefins bearing a tether with a directing group in a completely stereo‐ and regioselective manner. The stereo‐ and regioselectivity as well as excellent yields of tetrasubstituted olefins originated from the stabilization of a palladium intermediate by chelation between the palladium center and a directing group.

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