Copper‐Catalyzed Synthesis of Alkylphosphonates from  H ‐Phosphonates and  N ‐Tosylhydrazones | Zendy

Miao Wenjun | Zendy; Gao Yuzhen | Zendy; Li Xueqin | Zendy; Gao Yuxing | Zendy; Tang Guo | Zendy; Zhao Yufen | Zendy

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Copper‐Catalyzed Synthesis of Alkylphosphonates from H ‐Phosphonates and N ‐Tosylhydrazones

Author(s) -

Miao Wenjun,

Gao Yuzhen,

Li Xueqin,

Gao Yuxing,

Tang Guo,

Zhao Yufen

Publication year - 2012

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201200295

Subject(s) - chemistry , catalysis , copper , alkylation , iodide , organic chemistry , diphenylphosphine , medicinal chemistry , phosphine

A new catalytic system for the alkylation of H ‐phosphonates and diphenylphosphine oxide with N ‐tosylhydrazones has been developed. In the presence of copper(I) iodide and base, H ‐phosphonates react with N ‐tosylhydrazones to afford the corresponding coupled alkylphosphonates in good to excellent yields without any ligands. Alkylphosphonates can also be prepared in a one‐pot process directly from carbonyl compounds without the isolation of tosylhydrazone intermediates.

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