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Combining in situ Generated Chiral Silicon Lewis Acid and Chiral Brønsted Acid Catalysts for [3+2] Cycloadditions: Cooperative Catalysis as a Convenient Enantioselective Route to Pyrazolidines
Author(s) -
Serdyuk Olga V.,
Zamfir Alexandru,
Hampel Frank,
Tsogoeva Svetlana B.
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200293
Subject(s) - enantioselective synthesis , chemistry , phosphoric acid , catalysis , cycloaddition , lewis acids and bases , brønsted–lowry acid–base theory , chiral lewis acid , silicon , combinatorial chemistry , in situ , organocatalysis , organic chemistry , phosphate
A facile enantioselective synthesis of chiral pyrazolidines via a [3+2] cycloaddition reaction, involving a BINOL‐derived phosphoric acid and an in situ generated BINOL phosphate‐derived silicon Lewis acid, which may act cooperatively, has been developed.