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Lewis Acid‐Catalyzed Conjugate Addition of sp 3 CH Bonds to Methylenemalononitriles
Author(s) -
Qian Bo,
Shi Dengjian,
Yang Lei,
Huang Hanmin
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200285
Subject(s) - chemistry , conjugate , lewis acids and bases , nitrile , catalysis , surface modification , medicinal chemistry , lewis acid catalysis , addition reaction , polymer chemistry , combinatorial chemistry , stereochemistry , organic chemistry , mathematical analysis , mathematics
The Lewis acid‐catalyzed conjugate addition of 2‐alkylazaarenes to methylenemalononitriles through sp 3 CH bond functionalization has been developed, which provides an efficient and reliable method for incorporation of the nitrile group into the heterocycles.