Premium
Synthesis of Pyrimidopyrimidinediones in a Deep Eutectic Reaction Mixture
Author(s) -
Gore Sangram,
Baskaran Sundarababu,
Koenig Burkhard
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200257
Subject(s) - chemistry , eutectic system , deep eutectic solvent , tartaric acid , catalysis , solvent , work (physics) , reaction conditions , organic chemistry , combinatorial chemistry , thermodynamics , physics , alloy , citric acid
An efficient and general synthesis of hexahydropyrimidopyrimidinediones has been developed employing a low melting L ‐(+)‐tartaric acid‐dimethylurea mixture as reaction medium. The melt acts at the same time as solvent, catalyst and reactant. Functionalized hexahydropyrimidopyrimidinediones are obtained in good to excellent yields after simple work‐up.