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Rhodium‐Catalyzed Enantioselective Conjugate Addition of Arylboronic Acids to Dihydronitronaphthalenes
Author(s) -
Hajra Saumen,
Ghosh Rajib,
Chakrabarti Sagar,
Ghosh Amit,
Dutta Swarup,
Dey Tushar K.,
Malhotra Rajesh,
Asijaa Sonika,
Roy Subho,
Dutta Shantanu,
Basu Sourav
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200241
Subject(s) - enantioselective synthesis , rhodium , chemistry , conjugate , catalysis , phosphoramidite , ligand (biochemistry) , combinatorial chemistry , organic chemistry , receptor , biochemistry , dna , mathematical analysis , mathematics , oligonucleotide
A highly enantioselective (up to 91% ee ) rhodium‐catalyzed asymmetric addition of arylboronic acids has been achieved leading to the challenging dihydro‐3‐nitronaphthalenes using one equivalent of phosphoramidite ligand to rhodium catalyst. A concise formal asymmetric synthesis of the dopamine D1 agonist, dihydrexidine was accomplished using the method.

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