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Palladium‐Catalyzed C‐2 Selective CH Olefination of Pyridines
Author(s) -
Wen Ping,
Li Yanmei,
Zhou Kang,
Ma Chao,
Lan Xiaobo,
Ma Chaowei,
Huang Guosheng
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200195
Subject(s) - chemistry , palladium , olefin fiber , catalysis , styrene , combinatorial chemistry , acrylamide , organic chemistry , acrylic acid , copolymer , polymer
A novel and efficient protocol for the C‐2 selective olefination of pyridines via a palladium‐catalyzed oxidative cross‐coupling reaction has been developed. A wide range of pyridines and olefin substrates including acrylic ester, styrene, and acrylamide are compatible. The products are highly useful building blocks for the synthesis of bioactive alkaloid natural products and drug molecules.