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Diastereoselective Synthesis of Pyrazolines using a Bifunctional Brønsted Acidic Ionic Liquid under Solvent‐Free Conditions
Author(s) -
Safaei Shirin,
MohammadpoorBaltork Iraj,
Khosropour Ahmad R.,
Moghadam Majid,
Tangestaninejad Shahram,
Mirkhani Valiollah
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200191
Subject(s) - chemistry , bifunctional , ionic liquid , solvent , brønsted–lowry acid–base theory , organic chemistry , dimethyl acetylenedicarboxylate , green chemistry , catalysis , ionic bonding , cycloaddition , ion
An efficient protocol for the excellent diastereoselective synthesis of pyrazolines via a three‐component reaction of aldehydes, hydrazines and dimethyl acetylenedicarboxylate (DMAD) in the presence of a bifunctional Brønsted acidic ionic liquid as a reusable catalyst under solvent‐free conditions is reported. Easy work‐up, short reaction times, high yields of the products and an environmentally benign procedure avoiding toxic organic solvents are other significant features of this method.