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One‐Pot Tandem Synthesis of 2‐Arylbenzoxazole Derivatives via Copper‐Catalyzed CN and CO Bond Formation
Author(s) -
Kavala Veerababurao,
Janreddy Donala,
Raihan Mustafa J.,
Kuo ChunWei,
Ramesh Chintakunta,
Yao ChingFa
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200164
Subject(s) - chemistry , benzoxazole , nucleophile , catalysis , ligand (biochemistry) , imidazole , tandem , pyrazole , medicinal chemistry , indole test , combinatorial chemistry , copper , cascade reaction , coupling reaction , organic chemistry , biochemistry , materials science , receptor , composite material
The reaction of 2‐(2‐halophenyl)halobenzamides with a series of nitrogen nucleophiles resulted in the formation of benzoxazole derivatives. This procedure involves copper‐catalyzed one‐pot tandem CN/CO coupling reactions. No ligand was used in the reaction, even in the cases of primary or secondary amides, which were used as N‐nucleophiles. However, L ‐proline was used as ligand in the case of N‐aromatic heterocycles like indole, imidazole and pyrazole derivatives.