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Copper‐Catalyzed Activation of Dioxygen: Oxidative Cyclization of 2‐Arylindoles
Author(s) -
Sang Peng,
Xie Yongju,
Zou Jianwei,
Zhang Yuhong
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200162
Subject(s) - chemistry , quinoline , indole test , catalysis , copper , ring (chemistry) , oxidative coupling of methane , medicinal chemistry , combinatorial chemistry , polymer chemistry , photochemistry , stereochemistry , organic chemistry
A series of unusual six‐ring‐fused heterocycles containing indole and quinoline skeletons was successfully synthesized by a copper‐catalyzed reaction from 2‐arylated indoles. Two new bonds were regioselectively formed from CH and CH coupling. 18 O‐Labelled experiments revealed that the dioxygen is not only the oxidant but also the reactant.