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Alkylboronic Esters from Palladium‐ and Nickel‐Catalyzed Borylation of Primary and Secondary Alkyl Bromides
Author(s) -
Yi Jun,
Liu JinHui,
Liang Jun,
Dai JianJun,
Yang ChuTing,
Fu Yao,
Liu Lei
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200136
Subject(s) - chemistry , borylation , palladium , catalysis , alkyl , nickel , reagent , electrophile , ligand (biochemistry) , selectivity , primary (astronomy) , substrate (aquarium) , combinatorial chemistry , organic chemistry , aryl , biochemistry , receptor , physics , oceanography , astronomy , geology
Palladium‐ and nickel‐catalyzed cross‐coupling recations of unactivated alkyl bromides with diboron reagents have been developed as practical methods for the synthesis of primary and secondary alkylboronic esters. These reactions extend the concept and utility of Pd‐ and Ni‐catalyzed cross‐coupling of aliphatic electrophiles. They also show different substrate selectivity and ligand dependence as compared to the recently reported Cu‐catalyzed borylation reaction.