Premium
Iridium‐Catalyzed Enantioselective Allylic Alkylation of Methyl 2‐(4‐nitrophenylsulfonyl)acetate and Subsequent Transformations
Author(s) -
Xu QingLong,
Dai LiXin,
You ShuLi
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200113
Subject(s) - chemistry , enantioselective synthesis , tsuji–trost reaction , alkylation , iridium , allylic rearrangement , methyl acrylate , catalysis , organic chemistry , medicinal chemistry , copolymer , polymer
Highly enantioselective allylic alkylation reactions of methyl 2‐(4‐nitrophenylsulfonyl)acetate were carried out in the presence of an iridium catalytic system. The subsequent transformations of the products including reductive desulfonylation and modified Julia olefination led to the allylic alkylation products of methyl acetate or methyl acrylate with good yields and high enantioselectivity.