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Tetraflic Acid (1,1,2,2‐Tetrafluoroethanesulfonic Acid, HC 2 F 4 SO 3 H) and Gallium Tetraflate as Effective Catalysts in Organic Synthesis
Author(s) -
Prakash G. K. Surya,
Mathew Thomas,
Panja Chiradeep,
Kulkarni Aditya,
Olah George A.,
Harmer Mark A.
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200111
Subject(s) - chemistry , catalysis , gallium , salt (chemistry) , condensation , organic synthesis , organic chemistry , condensation reaction , strecker amino acid synthesis , heteropoly acid , enantioselective synthesis , physics , thermodynamics
Tetraflic acid offers ample acidity for various organic reactions that require high acidity. Its gallium(III) salt is an efficient catalyst under mild condtions for synthetic transformations such as the ketonic Strecker reaction for the synthesis of fluorinated α‐amino nitriles and condensation–cyclzation reactions using suitable fluoro ketones and 1,2‐disubstituted benzenes for the direct preparation of 5‐membered or 6‐membered fluorinated heterocycles.