Premium
Iron(III) Chloride‐Catalysed Aerobic Reduction of Olefins using Aqueous Hydrazine at Ambient Temperature
Author(s) -
Lamani Manjunath,
Ravikumara Guralamata S.,
Prabhu Kandikere Ramaiah
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200110
Subject(s) - chemistry , hydrazine (antidepressant) , aqueous solution , ferric , chloride , catalysis , reducing agent , inorganic chemistry , organic chemistry , chromatography
A chemoselective reduction of olefins and acetylenes is demonstrated by employing catalytic amounts of ferric chloride hexahydrate (FeCl 3 ⋅6 H 2 O) and aqueous hydrazine (NH 2 NH 2 ⋅H 2 O) as hydrogen source at room temperature. The reduction is chemoselective and tolerates a variety of reducible functional groups. Unlike other metal‐catalysed reduction methods, the present method employs a minimum amount of aqueous hydrazine (1.5–2 equiv.). Also, the scope of this method is demonstrated in the synthesis of ibuprofen in aqueous medium.