Premium
Palladium‐Catalyzed Selective CH Benzylation towards Functionalized Azoles with a Quaternary Carbon Center
Author(s) -
Xie Pan,
Huang Hanmin,
Xie Yinjun,
Guo Shengmei,
Xia Chungu
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200025
Subject(s) - chemistry , palladium , catalysis , quaternary carbon , bond cleavage , cleavage (geology) , organic chemistry , medicinal chemistry , carbon fibers , combinatorial chemistry , enantioselective synthesis , geotechnical engineering , fracture (geology) , engineering , materials science , composite number , composite material
The direct CH benzylation of azoles with benzyl chlorides proceeds efficiently, via sequential cleavage of one sp 2 CH bond and two sp 3 CH bonds in the presence of a palladium catalyst, to generate a wide range of tribenzylated azoles with a quaternary carbon center efficiently. The same catalyst could also promote the mono‐ and di‐benzylation reactions through fine turning of the base and reaction conditions.