Palladium‐Catalyzed Selective CH Benzylation towards Functionalized Azoles with a Quaternary Carbon Center | Zendy

Xie Pan | Zendy; Huang Hanmin | Zendy; Xie Yinjun | Zendy; Guo Shengmei | Zendy; Xia Chungu | Zendy

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Palladium‐Catalyzed Selective CH Benzylation towards Functionalized Azoles with a Quaternary Carbon Center

Author(s) -

Xie Pan,

Huang Hanmin,

Xie Yinjun,

Guo Shengmei,

Xia Chungu

Publication year - 2012

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201200025

Subject(s) - chemistry , palladium , catalysis , quaternary carbon , bond cleavage , cleavage (geology) , organic chemistry , medicinal chemistry , carbon fibers , combinatorial chemistry , enantioselective synthesis , geotechnical engineering , fracture (geology) , engineering , materials science , composite number , composite material

The direct CH benzylation of azoles with benzyl chlorides proceeds efficiently, via sequential cleavage of one sp 2 CH bond and two sp 3 CH bonds in the presence of a palladium catalyst, to generate a wide range of tribenzylated azoles with a quaternary carbon center efficiently. The same catalyst could also promote the mono‐ and di‐benzylation reactions through fine turning of the base and reaction conditions.

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