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Iron‐Catalyzed Efficient Synthesis of Amides from Aldehydes and Amine Hydrochloride Salts
Author(s) -
Ghosh Subhash Chandra,
Ngiam Joyce S. Y.,
Chai Christina L. L.,
Seayad Abdul M.,
Dang Tuan Thanh,
Chen Anqi
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200020
Subject(s) - chemistry , amine gas treating , amide , hydrochloride , catalysis , organic chemistry , combinatorial chemistry
A practical and efficient method for the synthesis of amides has been developed by iron‐catalysed oxidative amidation of aldehydes with amine hydrochloride salts. A wide range of amides have been obtained in good to excellent yields under mild conditions. The application of this novel amide formation reaction to the synthesis of pharmaceutical compounds has been successfully demonstrated.