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Evaluation of the Chiral DIANANE Backbone as Ligand for Organolithium Reagents
Author(s) -
Praz Jezabel,
Guénée Laure,
Aziz Sarwar,
Berkessel Albrecht,
Alexakis Alexandre
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201101016
Subject(s) - chemistry , enantioselective synthesis , reagent , amination , norbornane , aryl , aldimine , ligand (biochemistry) , deprotonation , reductive amination , organic chemistry , bromine , lithium (medication) , combinatorial chemistry , chiral ligand , catalysis , medicine , ion , biochemistry , alkyl , receptor , endocrinology
Novel endo,endo ‐2,5‐diaminonorbonane‐derived tertiary C 2 ‐symmetrical diamines were synthesized via the one‐pot reductive amination of enantiomerically pure norbornane‐2,5‐dione. These ligands were applied to various catalytic reactions such as asymmetric deprotonation, asymmetric bromine‐lithium exchange, and enantioselective addition of aryl‐ and allkylithium reagents to aromatic aldimines.