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N‐ Octanoyldimethylglycine Trifluoroethyl Ester, an Acyl Donor Leading to Highly Enantioselective Protease‐Catalysed Kinetic Resolution of Amines
Author(s) -
Queyroy Severine,
Vanthuyne Nicolas,
Gastaldi Stéphane,
Bertrand Michèle P.,
Gil Gérard
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201100993
Subject(s) - kinetic resolution , proteases , subtilisin , enantioselective synthesis , chemistry , serine protease , enantiomer , protease , serine , resolution (logic) , stereochemistry , organic chemistry , enzyme , catalysis , artificial intelligence , computer science
The use of N‐ octanoyldimethylglycine trifluoroethyl ester as acyl donor in the kinetic resolution of aliphatic amines catalysed by proteases led to enantiomeric ratios >200 in most cases. The resolutions mediated by Protex 6L were shown to be much faster than the resolutions achieved with the most efficient commercially available serine proteases, i.e., alkaline protease, Properase 1600L, and Subtilisin