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Copper‐Catalyzed Domino Synthesis of Isoquinolino[2,3‐ a ]quinazolinones
Author(s) -
Liu Tao,
Zhu Chongyu,
Yang Haijun,
Fu Hua
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201100951
Subject(s) - chemistry , domino , catalysis , copper , intramolecular force , combinatorial chemistry , organic chemistry , nucleophile , cascade reaction
A copper‐catalyzed domino method for synthesis of isoquinolino[2,3‐ a ]quinazolinones has been developed using readily available, substituted methyl 2‐(2‐haloobenzamido)benzoates and nitriles as the starting materials. The domino process comprises an Ullmann‐type C ‐arylation, intramolecular addition of NH with CN, and nucleophilic attack of amino to ester group. The inexpensive, convenient and efficient copper‐catalyzed method should provide a new and useful strategy for constructing nitrogen heterocycles.