Copper‐Catalyzed Domino Synthesis of Isoquinolino[2,3‐ a ]quinazolinones | Zendy

Liu Tao | Zendy; Zhu Chongyu | Zendy; Yang Haijun | Zendy; Fu Hua | Zendy

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Copper‐Catalyzed Domino Synthesis of Isoquinolino[2,3‐ a ]quinazolinones

Author(s) -

Liu Tao,

Zhu Chongyu,

Yang Haijun,

Fu Hua

Publication year - 2012

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201100951

Subject(s) - chemistry , domino , catalysis , copper , intramolecular force , combinatorial chemistry , organic chemistry , nucleophile , cascade reaction

A copper‐catalyzed domino method for synthesis of isoquinolino[2,3‐ a ]quinazolinones has been developed using readily available, substituted methyl 2‐(2‐haloobenzamido)benzoates and nitriles as the starting materials. The domino process comprises an Ullmann‐type C ‐arylation, intramolecular addition of NH with CN, and nucleophilic attack of amino to ester group. The inexpensive, convenient and efficient copper‐catalyzed method should provide a new and useful strategy for constructing nitrogen heterocycles.

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