Premium
Functionalizations of Aryl CH Bonds in 2‐Arylpyridines via Sequential Borylation and Copper Catalysis
Author(s) -
Niu Liting,
Yang Haijun,
Yang Daoshan,
Fu Hua
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201100930
Subject(s) - borylation , chemistry , aryl , sodium azide , reagent , halide , catalysis , iodide , combinatorial chemistry , halogen , copper , medicinal chemistry , organic chemistry , alkyl
Abstract Selective functionalizations of aryl CH bonds in 2‐arylpyridines have been developed via sequential borylation and aerobic oxidative copper catalysis, and the corresponding aryl halides, sulfones, azides and arylamines were obtained in good yields. The protocol uses cheap and readily available boron tribromide (BBr 3 ) as the borylating reagent, and inorganic salts (potassium iodide, ammonium bromide, sodium alkylsulfinates, sodium azide) as the functional group sources. This method makes functionalizations of aryl CH bonds easy.