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Olefin Metathesis on a TLC Plate as a Tool for a High‐Throughput Screening of Catalyst‐Substrate Sets
Author(s) -
Cabrera José,
Padilla Robin,
Dehn Richard,
Deuerlein Stephan,
Gułajski Łukasz,
Chomiszczak Ewa,
Teles J. Henrique,
Limbach Michael,
Grela Karol
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201100863
Subject(s) - catalysis , alkene , chemistry , thin layer chromatography , metathesis , silica gel , ring closing metathesis , substrate (aquarium) , ring opening metathesis polymerisation , chromatography , elution , organic chemistry , polymerization , polymer , oceanography , geology
A methodology for screening either various catalysts for a given metathesis reaction, i.e., ring opening‐ring closing alkene metathesis (RO‐RCM) and cross‐metathesis (CM), or various substrates for a given pre‐catalyst on a thin layer chromatography (TLC) plate has been developed. As the substrates elute with the solvent, this TLC‐based system acts as a heterogeneous catalyst bed (“TLC reactor”). Selected promising catalyst candidates were screened on a TLC plate and their initial catalytic potential as observed in the TLC test was later fully confirmed in a classical heterogeneous reaction set‐up using standard commercially available silica (D11‐10). Reacting polyfunctional, natural product‐like substrates in our TLC reactor allows the simultaneous screening of various substrates and the convenient micro‐scale preparation and isolation of potentially biologically active products.