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Core Scaffold‐Inspired Concise Synthesis of Chiral Spirooxindole‐Pyranopyrimidines with Broad‐Spectrum Anticancer Potency
Author(s) -
Jiang Xianxing,
Sun Yulong,
Yao Jia,
Cao Yiming,
Kai Ming,
He Ning,
Zhang Xiaoyuan,
Wang Yiqing,
Wang Rui
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201100792
Subject(s) - chemistry , broad spectrum , combinatorial chemistry , scaffold , enantioselective synthesis , computational biology , nanotechnology , biochemistry , computer science , biology , database , catalysis , materials science
Due to the lack of tumor‐specific anticancer agents, the discovery and development of new types of highly selective anticancer agents is still a very urgent topic. Herein, we present our contribution to concise construction of novel chiral spirooxindole‐type pyranopyrimidines exhibiting a unique profile of biological activities. We have found that this new type of spiro alkaloid could inhibit the proliferation of various cancer cells in a preliminary biological evaluation. These findings suggested that spirooxindole‐type pyranopyrimidines, developed by an asymmetric Michael/cyclization strategy, can potentially serve as a new kind of anticancer candidate.