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An Alternative Approach to Direct Aldol Reaction Based on Gold‐Catalyzed Methoxyl Transfer
Author(s) -
Zhang Moran,
Wang Yunxia,
Yang Yang,
Hu Xiangdong
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201100789
Subject(s) - aldol reaction , chemistry , catalysis , ligand (biochemistry) , combinatorial chemistry , aldol condensation , organic chemistry , addition reaction , receptor , biochemistry
A mild and catalyzed alternative to the direct aldol reaction has been developed based on the gold‐catalyzed methoxy group transfer from dimethyl acetals to terminal alkynes. Due to the simultaneous activation of the acetals, this aldol approach is only functional for acetals but not aldehydes. A ligand effect from the gold complex has also been observed.