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Highly Active Palladium Catalyst for the Sonogashira Coupling Reaction of Unreactive Aryl Chlorides
Author(s) -
Lee DongHwan,
Kwon YoungJun,
Jin MyungJong
Publication year - 2011
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201100747
Subject(s) - sonogashira coupling , chemistry , aryl , palladium , catalysis , copper , combinatorial chemistry , palladium catalyst , coupling reaction , organic chemistry , alkyl
This communication reports on the β‐diketiminatophosphane palladium‐catalyzed copper‐free Sonogashira coupling of aryl chlorides with alkynes. A catalyst loading of 0.5 mol% is sufficient to achieve high performance under relatively mild reaction conditions. Furthermore, dialkynylbenzenes are efficiently prepared by one‐pot double Sonogashira couplings of aryl dichlorides.