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Ene Reductase‐Catalysed Synthesis of ( R )‐Profen Derivatives
Author(s) -
Pietruszka Jörg,
Schölzel Melanie
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201100743
Subject(s) - chemistry , bacillus subtilis , ene reaction , reductase , enzyme , biocatalysis , stereochemistry , catalysis , organic chemistry , reaction mechanism , bacteria , genetics , biology
Enantiomerically pure ( R )‐profen derivatives and intermediates are synthesised utilising the enzyme YqjM, an ene reductase from Bacillus subtilis . After optimisation of the reaction conditions, the chemoenzymatic approach was applied for the first time in the synthesis of ( R )‐flurbiprofen methyl ester.
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