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Activation of 1,2‐Keto Esters with Takemoto’s Catalyst toward Michael Addition to Nitroalkenes
Author(s) -
Raimondi Wilfried,
Baslé Olivier,
Constantieux Thierry,
Bonne Damien,
Rodriguez Jean
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201100739
Subject(s) - michael reaction , chemistry , adduct , nucleophile , catalysis , organic chemistry , combinatorial chemistry
When activated with Takemoto’s catalyst, 1,2‐keto esters constitute versatile nucleophiles in the Michael addition reaction with nitroalkenes affording synthetically valuable, optically active anti‐ adducts in very good yields and high enantiomeric excesses.