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Iron‐Catalyzed Highly Enantioselective Reduction of Aromatic Ketones with Chiral P 2 N 4 ‐Type Macrocycles
Author(s) -
Yu Shenluan,
Shen Weiyi,
Li Yanyun,
Dong Zhenrong,
Xu Yaqing,
Li Qi,
Zhang Juanni,
Gao Jingxing
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201100733
Subject(s) - chemistry , enantioselective synthesis , catalysis , transfer hydrogenation , ligand (biochemistry) , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , ruthenium , receptor , biochemistry
Novel P 2 N 4 ‐donors containing chiral 22‐membered macrocyclic ligands have been synthesized and the structures have been determined by an X‐ray diffraction study. The catalytic systems in situ generated from triiron dodecarbonyl, Fe 3 (CO) 12 , and the chiral macrocyclic ligand exhibited high activity (TOF up to 1940 h −1 ) and excellent enantioselectivity with up to 99% ee in the asymmetric transfer hydrogenation of various aromatic ketones.
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