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Enantioselective Conjugate Addition of Nitroalkanes to Alkylidenemalonates Promoted by Thiourea‐Based Bifunctional Organocatalysts
Author(s) -
Chiarucci Michel,
Lombardo Marco,
Trombini Claudio,
Quintavalla Arianna
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201100732
Subject(s) - enantioselective synthesis , bifunctional , chemistry , conjugate , thiourea , cinchona , organocatalysis , organic chemistry , combinatorial chemistry , optically active , cinchona alkaloids , catalysis , mathematical analysis , mathematics
Cinchona alkaloids‐derived bifunctional thioureas efficiently catalyse the enantioselective conjugate addition of nitroalkanes to alkylidenemalonates with syn ‐diastereopreference, opening a route to the synthesis of optically active γ‐amino acid derivatives.