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Organocatalytic Enantioselective Synthesis of Pyrazolidines, Pyrazolines and Pyrazolidinones
Author(s) -
Fernández Maitane,
Reyes Efraím,
Vicario Jose L.,
Badía Dolores,
Carrillo Luisa
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201100722
Subject(s) - enantioselective synthesis , enantiopure drug , chemistry , hemiaminal , organocatalysis , squaramide , michael reaction , cascade , combinatorial chemistry , organic chemistry , stereochemistry , catalysis , chromatography
Enantiopure pyrazolidines, pyrazolines and pyrazolidinones have been accessed in a direct and efficient manner through an organocatalytic, enantioselective aza‐Michael/hemiaminal formation cascade process from enals and N , N′ ‐disubstituted hydrazides. The process takes place with high regio‐ and stereoselectivities and furnishes the target compounds in high overall yields by means of an operationally very simple methodology.