Premium
One‐Pot Hydroacetylation of Menadione (Vitamin K 3 ) to Menadiol Diacetate (Vitamin K 4 ) by Heterogeneous Catalysis
Author(s) -
Dobrinescu Claudiu,
Iorgulescu Elena E.,
Mihailciuc Constantin,
Macovei Dan,
Wuttke Stefan,
Kemnitz Erhard,
Parvulescu Vasile I.,
Coman Simona M.
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201100718
Subject(s) - menadione , chemistry , catalysis , selectivity , combinatorial chemistry , ionic bonding , fluoride , vitamin , organic chemistry , inorganic chemistry , ion , biochemistry , enzyme
Vitamin K 4 (menadiol diacetate, MDD) can be easily synthesized through cleaner and more efficient catalytic alternatives following the green chemistry principles. Ionic gold‐based hydroxylated fluorides are active bi‐functional catalysts for the one‐pot hydroacetylation of menadione leading to MDD with 77% selectivity. Unprecedent results were obtained in the presence of oxide‐fluoride catalysts by using a microwave‐assisted hydrogen‐transfer (Meerwein–Ponndorf–Verley reaction) coupled with an acetylation approach, yielding very high selectivities for the target product (95%).