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Thiourea‐Catalyzed Enantioselective Fluorination of β‐Keto Esters
Author(s) -
Xu Junxing,
Hu Yulai,
Huang Danfeng,
Wang KeHu,
Xu Changming,
Niu Teng
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201100660
Subject(s) - enantioselective synthesis , chemistry , bifunctional , thiourea , reagent , catalysis , organic chemistry , organocatalysis , halogenation , combinatorial chemistry
Bifunctional chiral thioureas have been successfully used as organocatalysts in enantioselective fluorinations of β‐keto esters. The corresponding products could be obtained with good to excellent enantioselectivity in high yields by using N ‐fluorobisbenzenesulphonimide (NFSI) as fluorination reagent.