Intramolecular Carbonyl Nitroso Ene Reaction Catalyzed by Iron(III) Chloride/Hydrogen Peroxide as an Efficient Tool for Direct Allylic Amination | Zendy

Atkinson Duncan | Zendy; Kabeshov Mikhail A. | Zendy; Edgar Mark | Zendy; Malkov Andrei V. | Zendy

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Intramolecular Carbonyl Nitroso Ene Reaction Catalyzed by Iron(III) Chloride/Hydrogen Peroxide as an Efficient Tool for Direct Allylic Amination

Author(s) -

Atkinson Duncan,

Kabeshov Mikhail A.,

Edgar Mark,

Malkov Andrei V.

Publication year - 2011

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201100632

Subject(s) - chemistry , allylic rearrangement , catalysis , ene reaction , amination , hydrogen peroxide , intramolecular force , nitroso , nitroso compounds , medicinal chemistry , iron(iii) chloride , organic chemistry , chloride , stoichiometry

A mild, simple oxidation protocol employing iron(III) chloride as a catalyst and hydrogen peroxide as a stoichiometric oxidant was found to be compatible with an intramolecular carbonyl nitroso ene reaction and allowed us to efficiently convert hydroxamic acids into a diverse range of 1,2‐ and 1,3‐amino alcohol derivatives in a single operation.

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