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Enantioselective Reaction of Imines and Benzyl Nitriles Using Palladium Pincer Complexes with C 2 ‐Symmetric Chiral Bis(imidazoline)s
Author(s) -
Hyodo Kengo,
Nakamura Shuichi,
Tsuji Kotaro,
Ogawa Takahiro,
Funahashi Yasuhiro,
Shibata Norio
Publication year - 2011
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201100626
Subject(s) - chemistry , enantioselective synthesis , palladium , pincer movement , imidazoline receptor , yield (engineering) , catalysis , benzene , medicinal chemistry , nitrile , organic chemistry , combinatorial chemistry , medicine , materials science , metallurgy
Enantioselective reactions of a wide variety of benzyl nitriles with N ‐tosylimines catalyzed by novel chiral 1,3‐bis(imidazolin‐2‐yl)benzene‐palladium(II) [Phebim‐Pd(II)] complexes have afforded the respective products in high yield with good enantioselectivity. A reaction mechanism is proposed based on X‐ray crystal structures of palladium complexes.