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Palladium‐Catalyzed Direct and Site‐Selective Desulfitative Arylation of Indoles with Sodium Sulfinates
Author(s) -
Wu Mingyue,
Luo Jiaying,
Xiao Fuhong,
Zhang Shufeng,
Deng GuoJun,
Luo HeAn
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201100603
Subject(s) - chemistry , palladium , catalysis , sodium , copper , combinatorial chemistry , organic chemistry
An efficient method was developed for the desulfitative arylation of indoles with sodium sulfinates using palladium as catalyst and copper chloride dihydrate as oxidant. The direct arylation occurred exclusively in the C‐2 position of indoles and proceeded well for a range of different substrates.