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The Iridium‐Catalyzed Synthesis of Symmetrically and Unsymmetrically Alkylated Diamines under Mild Reaction Conditions
Author(s) -
Michlik Stefan,
Hille Toni,
Kempe Rhett
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201100554
Subject(s) - chemistry , alkylation , iridium , reagent , catalysis , diamine , ligand (biochemistry) , organic chemistry , combinatorial chemistry , medicinal chemistry , biochemistry , receptor
An iridium catalyst – stabilized by an anionic P,N ligand – was used for the symmetrical and unsymmetrical monoalkylation of para ‐, meta ‐, and ortho ‐benzenediamines. Benzyl and aliphatic alcohols were used as alkylating reagents. 28 derivatives were synthesized. 14 of them are new compounds. Furthermore, the alkylation of the pharmacological important diamine Dapson ® (dapsone) is described. 14 dapsone derivatives were synthesized among them 9 new compounds.