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Selective Formation of Formamidines or 7‐Aminomethylbenzoxazoles from Unprecedented Couplings between Benzoxazoles and Amines
Author(s) -
Yu Dingyi,
Lee Szehui,
Sum Yin Ngai,
Zhang Yugen
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201100521
Subject(s) - chemistry , dichloromethane , amination , yield (engineering) , amine gas treating , ring (chemistry) , combinatorial chemistry , component (thermodynamics) , organic chemistry , catalysis , physics , solvent , materials science , metallurgy , thermodynamics
A method for the selective synthesis of amidines by ring‐opening amination or of 7‐aminomethylbenzoxazoles via a novel three‐component‐coupling reaction (arene, dichloromethane and amine) from benzoxazoles and amines was developed. Amidines could be further converted into 2‐aminobenzoxazoles in high yield.