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A Mild, Highly Efficient Addition of Alkynes to Aldehydes Catalyzed by Titanium Dioxide‐Supported Silver Nanoparticles
Author(s) -
Yu Min,
Wang Yong,
Sun Weijiang,
Yao Xiaoquan
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201100518
Subject(s) - chemistry , catalysis , triphenylphosphine , titanium dioxide , alkyne , alcohol , ligand (biochemistry) , titanium , nanoparticle , combinatorial chemistry , aldehyde , organic chemistry , nanotechnology , chemical engineering , biochemistry , materials science , receptor , engineering
Titanium dioxide‐supported silver nanoparticles were utilized as a highly efficient catalyst for the addition of terminal alkynes to aldehydes to prepare propargylic alcohols with the promotion by triphenylphosphine. Both a significant support effect and a ligand effect were observed in the catalytic reaction. With this protocol, various propargylic alcohol derivatives were synthesized from aldehydes and terminal alkynes in good to excellent yields. Furthermore, the catalyst could be recovered and reused effectively without obvious reduction in catalytic activity.