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The Growing Impact of Catalysis in the Pharmaceutical Industry
Author(s) -
Busacca Carl A.,
Fandrick Daniel R.,
Song Jinhua J.,
Senanayake Chris H.
Publication year - 2011
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201100488
Subject(s) - pharmaceutical industry , chemistry , biochemical engineering , catalysis , process (computing) , scale (ratio) , pharmaceutical manufacturing , organocatalysis , nanotechnology , organic chemistry , microbiology and biotechnology , computer science , engineering , enantioselective synthesis , bioinformatics , physics , materials science , quantum mechanics , biology , operating system
Catalysis has become increasingly important for the pharmaceutical industry. Catalysis is a critical technology that enables economical and environmentally‐sound manufacturing processes. The development of a viable catalytic process for industrial scales is a complex task that requires the collaboration of multiple disciplines. In this article, a number of selected, noteworthy industrial examples are discussed to showcase the catalytic technologies that have been successfully practiced on large scales for active pharmaceutical ingredient (API) synthesis, involving transition metal catalysis, biocatalysis and organocatalysis. In addition, several examples of potential and future catalytic transformations are included which can be utilized in pharmaceutical industry in large‐scale operational settings.