Direct Enantioselective Three‐Component Kabachnik–Fields Reaction Catalyzed by Chiral Bis(imidazoline)‐Zinc(II) Catalysts | Zendy

Ohara Mutsuyo | Zendy; Nakamura Shuichi | Zendy; Shibata Norio | Zendy

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Direct Enantioselective Three‐Component Kabachnik–Fields Reaction Catalyzed by Chiral Bis(imidazoline)‐Zinc(II) Catalysts

Author(s) -

Ohara Mutsuyo,

Nakamura Shuichi,

Shibata Norio

Publication year - 2011

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201100482

Subject(s) - chemistry , enantioselective synthesis , catalysis , zinc , yield (engineering) , enantiomer , pyridine , enantiomeric excess , organic chemistry , component (thermodynamics) , imidazoline receptor , ternary operation , medicinal chemistry , combinatorial chemistry , medicine , materials science , physics , metallurgy , thermodynamics , computer science , programming language

A direct three‐component reaction of aldehydes, amines and diaryl phosphites was catalyzed by a zinc(II) complex of 1,3‐bis(imidazolin‐2‐ly)pyridine (pybim) giving the corresponding α‐aminophosphonates in good yield with good enantioselectivity. The reaction was applied to a wide variety of aromatic aldehydes to give products with excellent yields (up to 99%) and enantiomeric excesses (up to 93% ee ).

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