Premium
Palladium‐Catalyzed Oxidative CH Bond Acylation of Acetanilides with Benzylic Alcohols
Author(s) -
Yuan Yu,
Chen Duanteng,
Wang Xiaowei
Publication year - 2011
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201100417
Subject(s) - chemistry , acetanilide , triflic acid , acylation , catalysis , aryl , palladium , yield (engineering) , organic chemistry , ketone , medicinal chemistry , alkyl , materials science , metallurgy
An efficient and clean method to construct CC bonds has been developed via the acylation reaction of acetanilides with benzylic alcohols using tert ‐butyl hydroperoxide (TBHP) as oxidant catalyzed by palladium acetate in the presence of triflic acid (TfOH). The acylation reactions exhibit excellent reactivities, and up to 95% yield of the corresponding aryl ketone could be obtained under the optimal conditions.