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Copper‐Catalyzed Synthesis of Indole‐Fused Benzodiazepines [1]
Author(s) -
Biswas Subhasish,
Batra Sanjay
Publication year - 2011
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201100388
Subject(s) - indole test , chemistry , catalysis , copper , combinatorial chemistry , benzodiazepine , organic chemistry , medicinal chemistry , biochemistry , receptor
The copper‐catalyzed synthesis of indole‐fused benzodiazepine via a cascade reaction between 3‐halo‐1 H ‐indole‐2‐carbaldehydes and substituted 1,2‐phenylenediamines is reported. Reactions with N‐Boc‐protected indole‐aldehydes are found to be more efficient to afford indole[3,2‐ b ][1,5]benzodiazepines.