Construction of Trifluoromethyl‐Bearing Quaternary Carbon Centers by Intramolecular Decarboxylative Allylation of α‐Trifluoromethyl β‐Keto Esters | Zendy

Shibata Norio | Zendy; Suzuki Satoru | Zendy; Furukawa Tatsuya | Zendy; Kawai Hiroyuki | Zendy; Tokunaga Etsuko | Zendy; Yuan Zhe | Zendy; Cahard Dominique | Zendy

Premium

Construction of Trifluoromethyl‐Bearing Quaternary Carbon Centers by Intramolecular Decarboxylative Allylation of α‐Trifluoromethyl β‐Keto Esters

Author(s) -

Shibata Norio,

Suzuki Satoru,

Furukawa Tatsuya,

Kawai Hiroyuki,

Tokunaga Etsuko,

Yuan Zhe,

Cahard Dominique

Publication year - 2011

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201100359

Subject(s) - chemistry , trifluoromethyl , tetrahydrofuran , medicinal chemistry , intramolecular force , palladium , fluoride , quaternary carbon , tris , catalysis , organic chemistry , alkyl , enantioselective synthesis , inorganic chemistry , biochemistry , solvent

A new palladium‐catalyzed decarboxylative allylation of allyl α‐trifluoromethyl‐β‐keto esters was developed in the presence of tris(dibenzylideneacetone)dipalladium [Pd 2 (dba) 3 ] and 1,2‐bis(diphenylphosphino)ethane (dppe) in tetrahydrofuran. α‐Trifluoromethyl ketones featuring a quaternary carbon center were produced in good yields and the dreaded α,β‐unsaturated‐β,β‐difluoro ketones resulting from β‐elimination of a fluoride ion was not observed.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research