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Phase‐Transfer‐Catalyzed Asymmetric Synthesis of 1,1‐Disubstituted Tetrahydroisoquinolines
Author(s) -
Shirakawa Seiji,
Liu Kun,
Ito Hironobu,
Le Thanh Nguyen,
Maruoka Keiji
Publication year - 2011
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201100269
Subject(s) - chemistry , catalysis , alkylation , enantioselective synthesis , combinatorial chemistry , phase (matter) , organocatalysis , stereochemistry , organic chemistry
A highly efficient catalytic asymmetric synthesis of 1,1‐disubstituted tetrahydroisoquinolines has been achieved via asymmetric alkylation or Michael addition of 1‐cyanotetrahydroisoquinolines using binaphthyl‐modified N ‐spiro‐type chiral phase‐transfer catalysts.