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Multi‐Enzymatic Cascade Reactions: Overview and Perspectives
Author(s) -
Ricca Emanuele,
Brucher Birgit,
Schrittwieser Joerg H.
Publication year - 2011
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201100256
Subject(s) - chemistry , cascade , bioprocess , biochemical engineering , cascade reaction , combinatorial chemistry , enzyme catalysis , organic chemistry , enzyme , nanotechnology , catalysis , chemical engineering , chromatography , engineering , materials science
Multi‐enzymatic cascade reactions, i.e., the combination of several enzymatic transformations in concurrent one‐pot processes, offer considerable advantages: the demand of time, costs and chemicals for product recovery may be reduced, reversible reactions can be driven to completion and the concentration of harmful or unstable compounds can be kept to a minimum. This review summarizes the developments in multi‐enzymatic cascades employed for the asymmetric synthesis of chiral alcohols, amines and amino acids, as well as for CC bond formation. In addition, a general classification of biocatalytic cascade systems is provided and bioprocess engineering aspects associated with the topic are discussed.